Dichotomy between Receptor-Interacting Protein 1– and Receptor-Interacting Protein 3–Mediated Necroptosis in Experimental Pancreatitis

Receptor-Interacting Protein Homotypic

بررسی میزان بیان آنزیم (receptor interacting protein 1 kinase (rip1k) در نمونه های جراحی بافت نرمال، خوش خیم و بدخیم پستان در خانم ها

مرگ سلولی برای هموستاز موجود زنده و بقای آن ضروری است. یکی از ویژگی های اصلی سلول¬های سرطانی، مقاومت در برابر مرگ است سلولهای سرطانی استراتژی های مختلفی را برای محدود کردن یا مقاومت در برابر آپوپتوز به کار می گیرند. مسیرهای مرگ سلولی توسط مجموعه¬ای از پروتئین¬ها و آنزیم¬ها کنترل می گردند. در حالت طبیعی سلول¬های آسیب دیده برای حفظ هموستاز بدن از بین می روند، اما سلول¬های سرطانی اغلب از طریق غیر ...

Actors of necroptosis scenario in cell\'s scene

Necroptosis, as a novel concept, has been recently introduced in scientific literature. Much of our knowledge about necroptosis comes from ligation of tumor necrosis factor-α to its receptor, TNF receptor 1. Receptor-interacting protein kinase 1, receptor-interacting protein kinase 3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been comprehensively st...

Differential cellular and subcellular localization of ampa receptor-binding protein and glutamate receptor-interacting protein.

Excitatory synaptic currents in the mammalian brain are typically mediated by the neurotransmitter glutamate, acting at AMPA receptors. We used immunocytochemistry to investigate the distribution of AMPA receptor-binding protein (ABP) in the cerebral neocortex. ABP was most prominent in pyramidal neurons, although it was also present (at lower levels) in interneurons. ABP and its putative bindi...

G-protein Coupled Receptor Dimerization

A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...